Mercedes-Benz S-Class Fuse Box Diagram and Location (2006-2013)
The fifth-generation Mercedes-Benz S-Class (W221), produced from 2006 to 2013, set new standards in luxury, comfort, and advanced technology. Featuring cutting-edge driver assistance systems, high-end interior materials, and powerful engine options, the W221 remains a popular choice for executives and automotive enthusiasts who demand refinement and performance.
In this article, you will find fuse box diagrams for the Mercedes-Benz S-Class, covering models S250, S280, S300, S320, S350, S400, S420, S450, S500, S550, S600, S63 AMG, and S65 AMG for the years 2006, 2007, 2008, 2009, 2010, 2011, 2012, and 2013. These diagrams provide essential insights into the fuse layout, helping vehicle owners, mechanics, and technicians locate and understand the function of each fuse and relay.
What’s Included:
Fuse Box Diagrams – Clear and detailed visuals to help identify fuses, relays, and circuit breakers.
Fuse Panel Locations – Step-by-step guidance on where to find the fuse panels inside the Mercedes-Benz S-Class.
Fuse Assignments – Comprehensive descriptions of each fuse and relay function for accurate diagnostics and troubleshooting.
Whether you’re searching for the fuse panel layout, replacing a blown fuse, or diagnosing an electrical issue, this guide is an essential resource. It ensures that your Mercedes-Benz S-Class’s electrical system remains functional and reliable for luxurious long-distance travel, high-performance driving, and everyday executive comfort.
Keep your Mercedes-Benz S-Class (2006–2013) operating at peak performance with this detailed fuse box, fuse panel, and relay guide!
The cigar lighter (power outlet) fuses in the Mercedes-Benz S-Class are:
The fuse box is located on the left side of the instrument panel, behind the cover.
Fuse box diagram
Assignment of the fuses in the Instrument Panel Fuse Box №1
№
Fused function
Amp
92
Left front seat control unit
40
93
Restraint systems control unit USA version: Weight Sensing System (WSS) control unit
7.5
94
from 2009: Multifunction camera
5
95
–
–
96
Tire pressure monitor [RDK] control unit
5
97
W221: Audio/video controller control unit (rear entertainment system)
7.5
98
Rear entertainment system: DVD player (from 2009)
7.5
99
from 2009: COMAND display, SPLITVIEW display
7.5
100
from 2009: Media interface control unit
5
101
Rear entertainment system: Left rear display, Right rear display
10
102
Right front seat control unit
40
103
ESP control unit
7.5
104
Audio tuner control unit
40
105
–
–
106
Japanese version: Electronic toll collection (ETC) control unit Valid for South Korea as of 1.9.10: TV/tuner connector Valid for navigation; from 2009: Navigation processor
1
107
SDAR control unit (SIRIUS satellite radio) (W221 from 2009) Digital radio: Digital Audio Broadcasting control unit HD radio: High definition tuner control unit
5
108
W221: Rear air conditioning control unit
5
109
W221: Rear blower intermediate connector
15
110
W221: Left rear multicontour backrest control unit, Right rear multicontour backrest control unit
7.5
111
Rear multicontour seat or rear entertainment system (model 221): RCP [HBF] control unit
5
112
W221; up to 2008: Left front door control unit, Right front door control unit S 400 Hybrid: Front SAM control unit with fuse and relay module
It is located between the rear seats. Swing down center armrest, open cover behind center armrest, pull cover 1 forward in direction of the arrow.
Fuse box diagram
Assignment of the fuses and relay in the Rear Fuse Box
№
Fused function
Amp
115
Heated rear window
50
116
Valid for engine 157, 275, 278: Charge air cooler circulation pump Valid for engine 156: Engine coolant circulation pump S 400 Hybrid: Power electronics circulation pump 2
10
117
Rear cigar lighter
15
118
Valid for engine 272, 273, 642: Fuel pump (up to 2008) Valid for model 221 with engine 629, 642: Fuel pump (from 2009)
30
118
S 400 Hybrid: Power electronics circulation pump 1 Valid for model 642.8 and engine 651 as of 1.6.11: Refrigerant compressor with magnetic
15
119
Front central operating unit
7.5
120
–
–
121
Audio tuner control unit
10
122
COMAND controller unit
7.5
123
W221: Right front reversible emergency tensioning retractor
40
124
W221: Left front reversible emergency tensioning retractor
40
125
up 31.5.09: Voice control system (VCS) control unit
5
126
Overhead control panel control unit
25
127
Lumbar pump (from 2009) Multicontour seat pneumatic pump (Left/right front multicontour seats) Pneumatic pump for dynamic seat control (Left and right dynamic multicontour seat)
30
128
Valid for engine 275 (up to 2008): Fuel pump control unit Valid for engine 156, 157, 272, 273, 275, 276, 278, 642 (from 2009): Fuel pump control unit
25
129
up to 2008: Overhead control panel control unit (Power glass tilting/sliding roof) from 2009: UPCI (Universal Portable Cell Phone Interface) control unit
25
130
Electric parking brake controller unit
30
131
Rear window antenna amplifier module
7.5
133
Trailer recognition control unit Reversing camera (as of 1.9.10)
15
134
Luggage compartment socket
15
135
Park Assist; up 2008: Radar sensors control unit (SGR) Front short range radar sensor unit Rear short range radar sensor unit DISTRONIC PLUS up to 31.8.10 or Blind Spot Assist or Adaptive cruise control Plus Light: Radar sensors control unit (SGR) (from 2009) PARKTRONIC or Exclusive parking assist: PTS control unit
7.5
136
Valid for model 221 with engine 642.8: AdBlue® control unit
7.5
137
Reversing camera (as of 1.9.10)
7.5
138
Navigation processor (from 2009) (up to 31.8.10) Emergency call system control unit (from 2009) Japanese version: TV/tuner connector (from 2009)
5
139
Rear backrest refrigerator box
15
140
Rear cigar lighter with ashtray illumination connector 115 V socket (from 2009)
15
141
Reversing camera control unit
5
142
Parktronic system (PTS) control unit Distronic Plus: Radar sensors control unit (SGR) Valid as of 1.9.10 for DISTRONIC PLUS and Active Blind Spot Assist or Active Lane Keeping Assist: Video and radar sensor system control unit
7.5
143
Rear seats control unit
25
144
Rear seats control unit
25
145
Trailer recognition control unit (up to 2008) Trailer hitch socket (13-pin) (from 2009)
20
146
Trailer recognition control unit
25
147
up to 2008: TLC [HDS] control unit (Remote trunk closing)
30
148
up to 2008: Universal Portable CTEL Interface (UPCI [UHI]) control unit
7.5
148
from 2009: Panoramic sliding sunroof circuit 30 connector sleeve
25
149
up to 2008: Voice control system (VCS [SBS]) control unit
5
149
from 2009: Panoramic sliding sunroof control module
25
150
TV combination tuner (analog/digital) Japanese version: TV/tuner connector (from 2009)
7.5
151
W221; up to 2008: Electric parking brake controller unit
25
151
W221; from 2009: Trailer recognition control unit
20
152
W221: Rear window antenna amplifier module
7.5
152
115 V socket: DC/AC converter control unit
25
Relay
M
Terminal 15 relay
N
Terminal 15R relay
O
Power outlet relay
P
Heated rear window relay
Q
Valid for engine 156, 157, 275, 278, 629: Circulation pump relay S 400 Hybrid: Valid for model 221.095/195: Power electronics circulation pump relay 2
R
Cigar lighter relay
S
Fuel pump relay Valid for engine 642.8 and engine 651 as of 1.6.11: Connected through the fuel pump: Refrigerant compressor magnetic clutch S 400 Hybrid: Power electronics circulation pump relay 1
The fuse box is located in the engine compartment (left-side on LHD, or right-side on RHD).
Fuse box diagram
Assignment of the fuses and relay in the Engine Compartment Fuse Box
№
Fused function
Amp
20
Valid for engine 629, 642, 651: CDI control unit Valid for engines 156, 157, 272, 273, 275, 276, 278: ME-SFI [ME] control unit
10
21
Valid for engines 156, 157, 272, 273, 275, 276, 278: Terminal 87 Ml i connector sleeve Valid for model 221 with engine 629 and engine 642: CDI control unit Fuel pump relay Valid for model 221 with engine 651: Quantity control valve
up to 2008: Terminal 87 connector sleeve Valid for engine 275 (model 216): Terminal 87 M1 i connector sleeve Valid for engine 273 (model 216): Terminal 87 M2e connector sleeve Valid for engine 272, 273 (model 221): Terminal 87M2i connector sleeve Valid for engine 642: Terminal 87 connector sleeve
from 2009: Valid for engine 156, 157, 272, 273, 275, 276, 278: Terminal 87 connector sleeve Valid for model 221 with engine 629 and engine 642: Terminal 87 connector sleeve Valid for engine 156, 157, 272, 273, 276, 278: Terminal 87M2e connector sleeve Valid for engine 275: Terminal 87 M2i connector sleeve Valid for model 221 with engine 629 and engine 642: Terminal 87 connector sleeve Valid for model 221 with engine 651: Rear SAM control unit with fuse and relay module
20
24
Valid for engines 157, 272, 273, 276, 278: Terminal 87Mle connector sleeve Valid for engine 642: CDI control unit
25
25
Instrument cluster
7.5
26
Left front lamp unit
10
27
Right front lamp unit
10
28
Valid for engine 275: EGS control unit Valid without engine 275: Fully integrated transmission control (VGS) control unit
7.5
29
Rear SAM control unit with fuse and relay module
5
30
Valid for engine 629, 642, 651: CDI control unit Valid for engines 156, 157, 272, 273, 275, 276, 278: ME-SFI [ME] control unit Fuel pump control unit
7.5
31
S 400 Hybrid: Electric refrigerant compressor
5
32
Valid for model with ECO start/stop function: Transmission oil auxiliary pump control unit S 400 Hybrid: Transmission oil auxiliary pump control unit
15
33
Valid as of 1.9.10 without model S 400 Hybrid: ESP control unit S 400 Hybrid: Battery management system control unit DC/DC converter control unit Power electronics control unit
5
34
S 400 Hybrid: Regenerative braking system control unit
5
35
Electric parking brake controller unit
5
36
Data link connector (Pin 16)
10
37
For EIS control unit
7.5
38
Central gateway control unit
7.5
39
Instrument cluster
7.5
40
Upper control panel control unit
7.5
41
Slave wiper motor
30
42
Master wiper motor
30
43
Front cigar lighter with ashtray illumination
15
44
–
–
45
S 400 Hybrid: Power electronics circulation pump 1
5
46
W221 with Active Body Control (ABC), model 216: ABC control unit W221 without Active Body Contro (ABC): AIRmatic with ADS control unit
15
47
Front SAM control unit with fuse and relay module Steering column up/down motor
15
48
up to 2008: Front SAM control unit with fuse and relay module
from 2009: Steering column in/out motor
15
49
Steering column module
10
50
AAC [KLA] control unit
15
51
up to 2008: COMAND display
7.5
51
from 2009: COMAND display SPLITVIEW display
5
52A
W221: Left fanfare horn Right fanfare horn
15
52B
W221, C216: Left fanfare horn Right fanfare horn
15
53
–
–
54
AC air recirculation unit
40
55
Valid for gasoline engine: Electric air pump
60
56
W221 without Active Body Contro (ABC): AIRmatic compressor unit
40
57
up 2008: Wiper park position heater
40
57
from 2009: Wiper park position heater
30
60
from 2009: Electrohydraulic power steering
5
61
C216; W221 – from 2009: Restraint systems control unit
7.5
61
W221; up to 2008: Restraint systems control unit
10
62
Night View Assist control unit
5
63
Valid for model 221 with engine 629 and engine 642 as of 1.9.08: Fuel filter condensation sensor with heating element
15
64
W221 as of 1.9.06: Driver NECK-PRO head restraint solenoid, Front passenger NECK-PRO head restraint solenoid
7.5
64
W221 as of ’09: Driver NECK-PRO head restraint solenoid, Front passenger NECK-PRO head restraint solenoid
10
65
Valid as of 1.6.09: 12 Volt connector in glove box
ECO start/stop function: ECO start/stop function relay S 400 Hybrid: DC/DC converter control unit Heated windshield: Heated windshield control unit
150
5
Valid for model 221 (Electrical preinstallation for rental vehicle): Special vehicle multifunction control unit (SVMCU [MSS])
125
5
S 400 Hybrid: Vacuum pump
40
6
Right dashboard fuse box
80
7
Valid for model 221 with engine 629, 642, 651: PTC heater booster Valid for model 221 (Electrical preinstallation for rental vehicle): Special vehicle multifunction control unit (SVMCU [MSS])
